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But it just turn ed out to be the best place for many reasons: more job opportunities for Terry and me; culture; food; great weathe r (if you don't count the smog); a stimulating, heterogeneous mix of people . We moved here in I 98 5 and into a very inter est- ing, beautiful, old (for Los Angeles) co.mmunity in the hills near downtown Los Angeles. We decided not to have kids, but we have two silly basset hounds, Tilly (the Hon) and Bridget, whom we love dearly and spoil rotten. They are just as important to us as your kids are to you, so don't be surprised when you start telling me about your kids, if I tell you about our dogs. After moving to Los Angeles I still work at USC . But now it's the Uni- versity of Southern California instead of the University of South Carolina. I was just promoted to (Full) Professor of Pathology, and I have a secondary appoint- ment with the Department of Biochemistry and M olecular Biology. I teach graduate students and medical students, but I spend most of my time running my research program, which is still funded by grants from the federal government. I have also .had some funding from the American Cancer Society. At any given time several graduate students, postdoctoral fellows, and technicians are usually working under my supervision and paid from the research grants that I have won to fund my research. We are trying to understand how stero id hormon es regulate the activities of cells in our bodies. Hormon es are the chemical messen- gers that travel from one organ to anothe r in our boclies. When they reach their target organ, they cause changes in the activity of specific genes in the cells of the target organ. Thi s is basic research , meaning that we are not dir ectly trying to cure any spec ific disease; we are just trying to understand how biological organisms and their cells work. Re sults from work like mine provide a basis of knowledge and technology upon whic h more practical studies to cure specific diseases are based. This type of basic research may soun d like a luxury, but the history of research has shown conclusive ly that practically oriented research can- not succeed without the technology and knowledge base provid ed by basic research. As time goes by I have become more and more dedicated to my research. I have been moderately successful as an academician. I have maintained continuous funding for my research by competing for grants from the federal government. I have served on several national grant review pan els and have pub- lished more than thirty pap ers in peer -revi ewed scientific journal s. I have graduated seven students from my lab wi th Ph.D . degrees, and some of them are now faculty member s at oth er univ ersities or scientists in industry. I have won some local teaching awards from my department. But of all the criteria I can judge my career by, research accomplishments are the most important to me; by that criterion, I am still somewhat disappoint ed so far. I would like to leave more of a mark on my field than I have so far. Unfortunately, it is not clear whether I will have the opportunity to continue my research much longer. Right now, because of the tight federal budget, funding is terribly difficult to obtain. I have lost one grant, but I still have another one for two more years. New proposals I have subm itt ed recently have been reviewed very favorab ly, but ther e were no funds available. If the funding situation doesn't improv e soon ... In spite of my disappointment in my research accomplishments to date, I